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No contraindications to this form of therapy in the form of toxic effects were observed in any patient in this series and all, except case, a patient who had atrial fibrillation and gross hypertension and died of a cerebrovascular accident months after treatment, have been followed up for at least three years.There are, however, good reasons why this form of therapy is unlikely to be of practical therapeutic value.In the first place the percentage of the dose of cyanocobalamin which is excreted increases as the dose is increased, the amount excreted being related not to the dose but to the logarithm of the dose, so that relatively little is gained in terms of deposition of vitamin B in tissues by the use of very large doses. In the second place the duration of effect of the cyanocobalamin retained in the body, as measured by the time for which the serum vitamin B, level remains above the lower limit of normal in patients with pernicious anaemia, is not directly proportional to the amount in tissues but related in a linear manner to the logarithm of the retained dose, so that a very great increase in the amount retained in the body causes only a slight increase in the duration of effect. For these reasons, and the obvious financial imit is doubtful if massive parenteral plications, injections of cyanocobalamin have anything to commend their use in clinical practice, at least in the maintenance therapy of patients with vitamin B deficiency states.No reason for this was found and it is possible that this is a biological abnormality.It is also possible that it was not pure cyanocobalamin but contained a proportion of the hydroxo form which may continue to be excreted for up to hours after injection.As this pattern of excretion was not seen in any other patient studied at this time and given the same dose and as the total amounts excreted were more in keeping with those excreted after an injection of cyanocobalamin than after an injection of hydroxocobalamin, the latter possibility seems less likely.It is clear that the amounts excreted in this late period were not large enough to have obscured any trend to the excretion of larger or smaller proportions of repeated injections of cyanocobalamin.and and the patients for their cooperation.Proceedings of the Isotope Technique Conference, Oxford, July, Vol.Proetctedbycopyright.http: jcpb. mj. com J ClinP athol: firstpublished as. jcp. on. J anu ary. Downo adedlfrom The copyright holder for   this <a href="http://www.targetmol.com/compound/Pamabrom">sell Pamabrom</a> preprint is the authorfunder.Alleviating these major limitations will increase the throughput of samples and, as a consequence, improve our understanding of the distribution and role of vitamin B in the oceans.In this study, the effect of flow rate on recovery of vitamin B was tested across a range of flow rates between and mL min using a commercial SPE cartridge containing surfacemodified styrene divinylbenzene.Recovery of vitamin B at flow rates up to the maximum rate tested did not statistically differ from mL min. A second study was conducted to determine whether storage of the SPE cartridges at C had a negative impact on vitamin B recovery.

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