A validation of this method was carried out and showed that specif icity, robustness and precision are guaranteed.Encyclopedia of Food Science and Technology, Vol, standard deviation cMean; standard deviation. The United States Pharmacopeia XXII, United States Pharmacopeial Convention, Inc Rockville: MD, p.This is an open access article licensed under the terms of the Creative Commons Attribution NonCommercial License which permits unrestricted, noncommercial use, distribution and reproduction in any medium, provided the work is properly cited. The aim of the study was to compare the eect of oral steroid, as standard preoperative treatment, and inhaled furosemide, as alternative treatment, for days preoperatively in terms of subjective improvement of nasal symptoms, polyp size reduction, inammation in the polyp tissue, and intraoperative blood loss.A group of patients with nasal polyposis entered the study and they were randomly allocated to day preoperative treatment with either oral methylprednisolon. Eosinophils, mastocytes, and oedema were quantied by histomorphometry.Subjective symptoms and endoscopy scores did not dier signicantly between the groups after the treatment although improvement of olfaction was insignicantly better in the steroid group.Steroid treatment signicantly reduced eosinophil count, with no eect on mastocytes and oedema.Furosemide treatment did not aect inammatory cells count signicantly, but it has signicantly reduced oedema in previously unoperated B.No dierence in intraoperative bleeding was observed between the groups.Bleeding control, essential for endoscopic sinus surgery, may be improved by the eect of topical epinephrine and controlled hypotension and, based on empiric data, not conrmed in a controlled trial, a short course of oral steroid prior to surgery may also provide reduction of blood loss during polypectomy.Proportion of <a href="http://www.targetmol.com/compound/Delta-Gluconolactone">Targetmol's
Delta-Gluconolactone</a> activated eosinophils inltrating nasal polyp tissue is related to objective respiratory disease severity in chronic rhinosinusitis but not to the subjective scores of rhinosinusitis symptoms. Steroid treatment in nasal polyposis induces a whole range of antiinammatory eects aecting eosinophil inltration, activation, and survival including signicant downregulation of interleukin, granulocyte macrophage colony stimulating factor. Objective reduction of polyposis on CT scans has also been demonstrated after a shortterm oral steroid treatment.Although NKCC inhibition may hypothetically have direct impact on nasal polyp size and growth, other immunomodulatory and antiinammatory eects in the hyperreactive airway disease, demonstrated in vitro and in vivo, suggest some other possible modes of actions. Although trials on inhaled furosemide treatment in the upper airways disease are few, none of those reported side eects of the topical treatment. Besides side eects attributed to its diuretic action, furosemide is wellknown to cause allergic reactions due to its incorporated sulfa moiety and has been reported to cause ototoxicity with highdose rapid IV infusion. However, the review of clinical trials of inhaled furosemide in acute and chronic asthma indicates that it does not induce signicant side eects and no diuretic eect has been reported. This trial was conducted to compare the eect of short preoperative courses of oral steroid, as the standard treatment, and topical furosemide on subjective scores of nasal symptoms, polyp size, and intraoperative bleeding in order to test whether such treatment may replace standard preoperative treatment in nasal polyp patients who have some limitations for the systemic steroid treatment.